Transformation of resident notochord‐descendent nucleus pulposus cells in mouse injury‐induced fibrotic intervertebral discs
نویسندگان
چکیده
منابع مشابه
Acid-sensing ion channel 1a regulates the survival of nucleus pulposus cells in the acidic environment of degenerated intervertebral discs
Objective(s): Activation of acid-sensing ion channel 1a (ASIC1a) is responsible for tissue injury caused by acidosis in nervous systems. But its physiological and pathological roles in nucleus pulposus cells (NPCs) are unclear. The aim of this study is to investigate whether ASIC1a regulates the survival of NPCs in the acidic environment of degenerated discs. Materials and Methods: NPCs were i...
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STUDY DESIGN Senescence-related markers were assessed in surgically obtained human nucleus pulposus (NP) specimens. PURPOSE To demonstrate the mechanism and signaling pathway involved in the senescence of NP chondrocytes. OVERVIEW OF LITERATURE The population of senescent disc cells has been shown to be increased in degenerated or herniated discs. However, the mechanism and signaling pathwa...
متن کاملAdipose-derived stem cells improve the viability of nucleus pulposus cells in degenerated intervertebral discs.
Patients with degenerative disc disease (DDD) experience serious clinical symptoms, including chronic low back pain. A series of therapies have been developed to treat DDD, including physical therapy and surgical treatment. However, the therapeutic effect of such treatments has remained insufficient. Recently, stem cell‑based therapy, in which stem cells are injected into the nucleus pulposus i...
متن کاملIdentification of critical genes in nucleus pulposus cells isolated from degenerated intervertebral discs using bioinformatics analysis
Intervertebral disc (IVD) degeneration is a pathological process, which may lead to lower back pain. The present study aimed to investigate the pathogenesis of IVD degeneration. GSE42611 was downloaded from Gene Expression Omnibus, including 4 nucleus pulposus samples isolated from degenerated IVDs and 4 nucleus pulposus samples separated from normal IVDs. The differentially expressed genes (DE...
متن کاملacid-sensing ion channel 1a regulates the survival of nucleus pulposus cells in the acidic environment of degenerated intervertebral discs
objective(s): activation of acid-sensing ion channel 1a (asic1a) is responsible for tissue injury caused by acidosis in nervous systems. but its physiological and pathological roles in nucleus pulposus cells (npcs) are unclear. the aim of this study is to investigate whether asic1a regulates the survival of npcs in the acidic environment of degenerated discs. materials and methods: npcs were is...
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ژورنال
عنوان ژورنال: Aging Cell
سال: 2020
ISSN: 1474-9718,1474-9726
DOI: 10.1111/acel.13254